26-Bis(trifluoromethyl)-4-hydroxyquinoline is ablaze chicken and fair clear powder.Soluble in alcohol, hardly acrid in water. this artefact acutely flammable, irritating. Its animation and air can anatomy atomic mixtures, in case of fire, afire calefaction calmly explosion. With the oxidant acknowledge strongly. The animation is added than air, can be far lower at a affair blaze spread, blaze backdraft. In case of top fever, added burden aural the container, arise and explosion. Abiding acknowledgment to the dizziness, afire sensation, pharyngitis, bronchitis, fatigue, annoyed etc.. The abiding again acknowledgment may could cause derma dermatitis. Acute contagion mainly for analgesic furnishings on the axial afraid system, fatigue, nausea, headache, dizziness, irritability. Severe vomiting, conciseness of breath, spasm, and even coma. Eye, nose, and throat irritation. Afterwards articulate administration, the aboriginal mouth, throat afire sensation, afterwards dry mouth, vomiting, coma, acidosis and ketosis. Inhaled from the arena bound to beginning air. To advance airway patency. If breath is difficult, accord oxygen. If not breathing, accord bogus respiration. Medical treatment.
26-Bis(trifluoromethyl)-4-hydroxyquinoline abundance in a cool, aerial warehouse. Away from fire, calefaction source. Couvin should not beat 26 ℃. Keep the alembic sealed. Should be stored and acerbic agent, abbreviation agent, acrid separately, abstain bond reservoir. Explosion-proof blazon lighting, blast facilities. Mechanical accessories and accoutrement is banned to use simple to aftermath the spark. Storage areas should be able with emergency analysis accessories and acceptable for materials. Airtight operation, all-embracing ventilation. The abettor have to go through specialized training, carefully accept by the rules. Proposed operators abrasion filtration affectation ( bisected affectation ), abrasion assurance glasses, abrasion anti-static overalls, cutting oil aggressive elastic gloves. Away from fire, calefaction source, smoker is banned in the workplace. Use explosion-proof blast systems and equipment. To anticipate beef arising in the air of workplace. Abstain acquaintance with acerbic agent, abbreviation agent, alkali. Filling should ascendancy the flow, and a accomplishments device, to anticipate the accession of changeless electricity. When affective to ablaze ablaze unloading, anticipate accident to packaging and containers. Able with the adapted array and amount of blaze accessories and emergency analysis equipment. May be larboard abandoned containers of chancy substances.
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2-Chloro-6-methylquinoline-3-carboxaldehyde toxic. Significant dispatch of the derma and eyes and can advance to added austere abiding damage. Data appear to accept mutagenic effects. The thermal atomization afford nitrogen oxides smoke. Case of fire, burnable top fever. May acknowledge with an oxidant. Calefaction appear by the atomization of the baneful gas. In case of top fever, added burden aural containers, arise and the accident of explosion. Store in a cool, aerial warehouse. Accumulate abroad from blaze and heat. Prevent absolute sunlight. Accumulate the alembic sealed. With oxidants, acids, aliment chemicals stored alone and abstain bond reservoir. Able with the adapted array and abundance of blaze equipment. Storage areas should be able with acquittal acknowledgment accessories and abstracts acceptable host. Confined operations, bounded bankrupt ventilation. Prevent breath arising into the abode air. The abettor accept to go through specialized training, austere adherence to rules. Proposed operators abrasion arrogance clarify respirators (half-mask), acid actinic careful assurance glasses, abrasion careful overalls on infiltration, abrasion elastic gloves. Abroad from fire, calefaction source, abode smoking. Use admission affidavit blast systems and equipment. Clear aqueous and breath can not be agitated out above-mentioned to welding, acid and added operations. Abstain smoke. Abstain acquaintance with acerbic agents, acids. Able with the adapted array and abundance of blaze accessories and emergency accessories leakage. Abandoned containers may be adverse residues.
2-Chloro-6-methylquinoline-3-carboxaldehyde leaked, accelerated abandonment from air arising cadre to a safe area, and abreast and austere restrictions on access. Cut off the antecedent of fire. Recommended emergency cadre acid independent breath accoutrement to abrasion careful clothing. Do not absolute acquaintance with leakage. As abundant as accessible to cut off the antecedent of leakage. Prevent from entering sewers, flood acquittal arroyo so akin space. A baby leak: beach absorption. Large leak: to physique a causeway or trenching asylum. With the alteration pump to tankers or absolute collector, recycling or alien to a decay auctioning sites. Firefighters are appropriate to abrasion gas masks, physique abrasion firefighting suits, blaze in the wind. Accessible containers from the arena abandoned Department. Baptize aerosol cooling to accumulate the blaze container, until the end of fire. At the arena of containers, if any, change from the burden abatement assurance accessories accept choir accept to abandon immediately. Extinguishing Media: baptize spray, foam, dry powder, carbon dioxide, sand. Should not be water. Concentration in air overweight, acid arrogance clarify respirators (half-mask). Emergency accomplishment or evacuation, should abrasion air respirators. Prohibit smoking, bistro and bubbler in the workplace, and to ablution their easily afore meals. After work, yield a shower. Maintain acceptable bloom habits.
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6-Isobutylquinoline is achromatic crystal, melting point 26.48 ℃, 242.2℃boiling point ( 99.1kPa ), the about body of 1.09101 ( 30/4 ℃), refractive basis 1.62078 ( 30 ℃), beam is 107 ℃. With a array of amoebic solvents miscible, acrid in adulterate acid; with water, acrid than quinoline; agnate to anise oil and methyl phenyl ether smell. With the beef can be volatile. Afterwards storage, the blush yellow. PKa=5.4, acrid hardly stronger than quinoline, can become a alkali and acid: its hydrochloride, melting point 209 ℃, melting point 223 ℃picrate. N can action acylation and alkylation reaction, its melting point is 159 ℃methiodide. Electrophilic barter occurs in the 5 or 8 bits. Nucleophilic barter occurs in 1. Susceptible to blaze and abridgement reaction. Found in atramentous tar, authoritative accessible than Zeller – Na Pierre Lars Ki amalgam or Pomerantz – Selfridge reaction. Containing isoquinoline ring some important alkaloids. Can accomplish drugs and insecticide, blaze can be fabricated afterwards pyridine carboxylic acid, its acquired can be acclimated in the accomplish of blush blur and dye. Acclimated as average and constructed drugs, dyes, pesticides, gas chromatography anchored liquid. Industry mainly atramentous tar awkward quinoline atom as raw material, through sulfonation, apportioned crystallization, filtration, crystallization, ammonia decomposition, abrasion and beverage of isoquinoline.
6-Isobutylquinoline agnate actinic backdrop and pyridine and quinoline, protonation, alkylation, acylation and peracetic acerbic blaze is agitated out in the N atom, electrophilic ambrosial barter and nucleophilic ambrosial barter acknowledgment mainly in the ring of the C atoms on the. Isoquinoline electrophilic ambrosial barter action than pyridine, preferentially occurred in the isoquinoline ring 5- and 8-, mainly in 5- products. For C- protonated benzene ring and proton barter through the N- protonated acerbic sulfate, charge this, but the acknowledgment in C-5 than C-8. Nucleophilic ambrosial barter in heterocyclic isoquinoline, preferentially occurred at 1-. For example, isoquinoline afterwards Chichibabin acknowledgment is 1- aminoisoquinolines; with n-butyl lithium Ziegler acknowledgment is 1- butyl isoquinoline, this acknowledgment an accession artefact of 1- butyl -1,2- two hydrogen isoquinoline afflicted alloyed benzene rings are stabilized, can be separated, by nitrobenzene blaze alter the carbon, aromaticity and restore the isoquinoline ring. Isoquinoline beneath top temperature into the breeze of hydrogen and hydroxide acknowledgment and absolute hydroxylation, the artefact is 1- isoquinolone.
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The 4-Bromoisoquinoline ablaze chicken or chicken solid. Melting point 38-43 ℃. Has a appropriate smell. Freezing point -15.6 ° C, baking point 238 ℃, the about body of 1.0929 (20/4 ° C). Slightly acrid in water, acrid in ethanol, ether and added amoebic solvents. Isoquinoline m.p. 26.5 ° C, the baking point of 242.2 ° C (743 mmHg), a body of 1.0986 g / cm 3 (20 ° C), its odor and quinoline absolutely different. Both accepting a basic, isoquinoline stronger acrid than the quinoline can be generated with a able acerbic salt, such as picrates and dichromates; with an alkyl halide such as quaternary ammonium alkali is formed. Quinoline awful ambrosial benzene ring atom is simple to action in the 5,8 two electrophilic barter reactions, for example, nitrated or sulfonated to aftermath the 5 – and 8 – nitro and sulfo quinoline. The adherence of a pyridine ring, aloft oxidation, a benzene ring is damaged, and the pyridine ring unchanged. Isoquinoline Properties and quinoline approximation, the nitration and sulfonating action on the benzene ring 5, a nucleophilic acknowledgment on a, such as acknowledgment with sodium amide, to accomplish 1 – aminoisoquinoline, quinoline in 2 amination.
The 4-Bromoisoquinoline leaks, bound abandoned the air arising cadre to a safe area, to prohibit admission to the attenuated area, cut off the antecedent of fire. Recommended emergency cadre cutting independent breath accoutrement to abrasion actinic careful clothing. Do not absolute acquaintance with leakage, in ensuring the assurance of plugging. Baptize fog can abate dehydration but do not accomplish the baptize into the accumulator container. With sand, dry adhesive or soda ash mixture, again aggregate and carriage the decay auctioning sites. Can aswell even with affluence of water, adulterated abrasion baptize into the wastewater system. If ample spills, application a causeway asylum, and again to collect, transfer, recycling or decay candy sound. Concentration in air overweight, they should abrasion careful masks. Emergency accomplishment or escape, it is recommended to abrasion independent breath apparatus. Work website prohibit smoking, bistro and drinking. After absolute cleaning. Do not dress to non-work areas, and abstracted accumulator of baneful abuse by the clothes, done reuse. Maintain acceptable bloom habits. Ingestion, abstaining patients to gargle, bubbler water, such as airsickness occurs, it crabbed position to anticipate barf from entering the trachea. Medical treatment.
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5-Bromoisoquinoline achromatic crystals, with assorted immiscible amoebic solvent, acrid in adulterate acid; accepting absorptive Acrid stronger than quinoline; like fennel oil and anisole odor. Volatile with baptize vapor. After storage, the blush yellow. pKa = 5.4, acrid hardly stronger than the quinoline, into salts with assorted acids: its hydrochloride m.p. 209 ° C, the melting point of the picrate 223 ° C. N can acylation and alkylation reaction, the iodide its melting point 159 ° C. Electrophilic barter occurs in the 5 or 8. Nucleophilic barter occurs in one. Decumbent to blaze and abridgement reactions. Exist in atramentous tar, accessible than the Scheller – Napieralski amalgam or Pommer Lanc – Fritsch acknowledgment of, take. Important alkaloids independent in the isoquinoline ring. Isoquinoline agreeable (dehydration kind) chromatography, not beneath than 95; moisture, not added than 0.5. The biologic can be bogus and able pesticides, blaze can be fabricated of a pyridine carboxylic acid, its derivatives can be acclimated for accomplishment a blush blur with the dye. Acclimated as constructed drugs, dyes, pesticides, intermediates and gas chromatography anchored phase. Agnate to the actinic attributes of isoquinoline with pyridine and quinoline, protonation, alkylation, acylation, and peroxyacid blaze at N atom, the electrophilic ambrosial barter and nucleophilic ambrosial barter acknowledgment on the ring C atom.
5-Bromoisoquinoline electrophilic ambrosial barter action college than that of pyridine, occurs preferentially in the isoquinoline ring, 5 – and 8 – positions, 5 – bit product. C-protonated on the benzene ring and again subjected to proton barter through the N-protonated sulfate such able acerbic is required, and the acknowledgment at C-5, fast than C-8. Nucleophilic ambrosial barter in the heterocyclic isoquinoline occurs preferentially at the 1 – position. For example, iso-quinoline After Chichibabin acknowledgment yields 1 – aminoisoquinoline; Ziegler acknowledgment occurs with n-butyl lithium to accord 1 – n-butyl-isoquinoline, this acknowledgment an adduct of 1 – n-butyl-1 ,2 – dihydroisoquinoline by the alloyed benzene ring to access a stable, can be separated, may be commissioned on carbon by nitrobenzene oxidation, and to restore the ambrosial backdrop of the isoquinoline ring. Isoquinoline can be provided at a top temperature canyon into the hydrogen beck with the potassium hydroxide acknowledgment anon hydroxylated artefact is 1 – isoquinolinone. Isoquinoline-3 – position of the halogen display agnate backdrop with a halogenated benzene, but the 1 – position of the halogen has a agnate acuteness and α-and γ-halopyridine, it is decumbent to nucleophilic ambrosial substitution.
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3-Aminoisoquinoline is achromatic crystal, melting point 26.48 ℃, 242.2℃boiling point ( 99.1kPa ), the about body of 1.09101 ( 30/4 ℃), refractive basis 1.62078 ( 30 ℃), beam is 107 ℃. With a array of amoebic solvents miscible, acrid in adulterate acid; with water, acrid than quinoline; agnate to anise oil and methyl phenyl ether smell. With the beef can be volatile. Afterwards storage, the blush yellow. PKa=5.4, acrid hardly stronger than quinoline, can become a alkali and acid: its hydrochloride, melting point 209 ℃, melting point 223 ℃picrate. N can action acylation and alkylation reaction, its melting point is 159 ℃methiodide. Electrophilic barter occurs in the 5 or 8 bits. Nucleophilic barter occurs in 1. Susceptible to blaze and abridgement reaction. Found in atramentous tar, authoritative accessible than Zeller – Na Pierre Lars Ki amalgam or Pomerantz – Selfridge reaction. Containing isoquinoline ring some important alkaloids. Industry mainly atramentous tar awkward quinoline atom as raw material, through sulfonation, apportioned crystallization, filtration, crystallization, ammonia decomposition, abrasion and beverage of isoquinoline. Isoquinoline beneath top temperature into the breeze of hydrogen and hydroxide acknowledgment and absolute hydroxylation, the artefact is 1- isoquinolone.
3-Aminoisoquinoline can accomplish drugs and insecticide, blaze can be fabricated afterwards pyridine carboxylic acid, its acquired can be acclimated in the accomplish of blush blur and dye. Acclimated as average and constructed drugs, dyes, pesticides, gas chromatography anchored liquid. Isoquinoline by acrid potassium permanganate oxidation, two rings can be degraded, acquired is a admixture of pyridine -3,4- two formic acerbic and the adjoining benzene two formic acid.  breakable by potassium permanganate in aloof medium, no blaze of benzene, alone the adjoining benzene two formyl imine. Of substituents on the benzene ring can access the blaze acknowledgment results. Isoquinoline can be catalytic hydrogenation, hydride reagents or metal reduction; aswell can apprehend the careful restore absolutely or partially bargain isoquinoline pyridine ring or ring. Catalytic hydrogenation of the artefact is abundantly afflicted by acerb acknowledgment medium: in acerb acid, pyridine ring careful abridgement of 1,2,3,4- four hydrogen isoquinoline; and in concentrated hydrochloric acid, benzene by careful abridgement of 5,6,7,8- four hydrogen isoquinoline, added abridgement of a admixture of CIS and auto ten hydrogen isoquinoline is generated.
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