Using: Spice average body, anesthetic intermediate, agreement reagent.

Trimethylsilylacetylene is an acetylene atom adequate on one end by the trimethylsilyl group. It is bargain acclimated in alkynylations, e.g. the Sonogashira reaction. After desilylation (e.g. with TBAF), the ethynyl accumulation is introduced. Using a adequate alkyne, as against to acetylene gas, prevents added (undesired) coupling reactions and aswell has the account of getting a liquid.

This admixture is commercially available. It may aswell be able in a address agnate to added silyl compounds: deprotonation of acetylene with a Grignard reagent, followed by acknowledgment with trimethylsilyl chloride.

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Chemical raw material

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