Venlafaxine was aboriginal actinic in the aboriginal 1980s by advisers at Wyeth Pharmaceuticals. Wyeth scientists accustomed venlafaxine’s affiance as an important antidepressant and apprenticed advanced with its development. Wyeth launched venlafaxine for the analysis of abasement in the United States in aboriginal 1994 beneath the barter name Effexor.

The anesthetic was originally launched in an actual absolution formulation. The extended-release (XR) conception was accustomed by the FDA in 1997. The advantage of the XR formulation, besides once-daily dosing, is a hardly lower amount of abhorrence during the alpha of therapy.