Chloramphenicol was originally acquired from the bacillus Streptomyces venezuelae, abandoned by David Gottlieb, and alien into analytic convenance in 1949, beneath the barter name Chloromycetin. It was the aboriginal antibacterial to be bogus synthetically on a ample scale.

The contemporary conception of chloramphenicol was frequently acclimated as eye drops as first-line analysis of conjunctivitis. The aboriginal accident from eye drops was appear in 1955.

In 2007, the accession of letters advertence aplastic anemia and claret dyscrasia with chloramphenicol eye drops advance to the allocation of “probable” according to World Health Organization criteria, based on the accepted appear case letters and the ad-lib letters submitted to the National Registry of Drug-Induced Ocular Side Effects.