Unlike the all-over careful serotonin reuptake inhibitors (SSRIs) which abominably and globally drag serotonin in the brain, Tianeptine modulates abundant pathways and neurotransmitters, including glutamate, dopamine, serotonin and the opioid system.

Tianeptine is a abounding agonist at mu-opioid receptors. The autogenous ligand for mu-opioid receptors is enkephalins and beta-endorphins in the brain. These are the aforementioned neuropeptides amenable for the mood-elevating furnishings of exercise (the alleged “runner’s high”).

In added respects, Tianeptine recapitulates the benign furnishings of exercise on cognition. For example, it has been appropriate that Tianeptine prevents stress-induced synaptic adjustment in a address akin to exercise.

Tianeptine abundantly promotes mesolimbic dopamine absolution and potentiates some subtypes of the dopamine receptor, by an uncharacterized mechanism.

Tianeptine aswell acceptable alters the phosphorylation accompaniment of glutamate receptors. This accentuation of excitatory neurotransmission in the hippocampus and abroad may underlie Tianeptine’s neuroprotective effects.

Tianeptine is apparently the a lot of atypical psychiatric biologic currently assigned for abasement (in Europe). Tianeptine affects the opioid arrangement (via mu-opioid agonism), glutamate receptors, and reverses stress-induced impairments in neuroplasticity.