Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into alive triphosphate. Stavudine triphosphate inhibits the HIV about-face transcriptase by aggressive with accustomed substrate, thymidine triphosphate. It aswell causes abortion of DNA archetype by accumulation into the DNA strand.
Simultaneous use of zidovudine is not recommended, as it can arrest the intracellular phosphorylation of stavudine. Other anti-HIV drugs do not acquire this property.
Stavudine is a nucleoside about-face transcriptase inhibitor (NRTI) with action adjoin Human Immunodeficiency Virus Type 1 (HIV-1). Stavudine is phosphorylated to alive metabolites that attempt for assimilation into viral DNA. They arrest the HIV about-face transcriptase agitator competitively and act as a alternation terminator of DNA synthesis. The abridgement of a 3′-OH accumulation in the congenital nucleoside alternation prevents the accumulation of the 5′ to 3′ phosphodiester bond capital for DNA alternation elongation, and therefore, the viral DNA advance is terminated.