Sodium Hexametaphosphate is acclimated as a sequestrant and has applications aural a advanced array of industries, including as a aliment accretion in which it is acclimated beneath the E amount E452i. Sodium carbonate is sometimes added to Sodium Hexametaphosphate to accession the pH to 8.0–8.6, which produces a amount of Sodium Hexametaphosphate articles acclimated for baptize abatement and detergents.

A cogent use for sodium hexametaphosphate is as a deflocculant in the assembly of clay-based bowl particles. It is aswell acclimated as a dispersing abettor to breach down adobe and added clay types.

It is acclimated as an alive additive in toothpastes as an anti-staining and tartar blockage ingredient.