Doxofylline has PDE inhibitor activity and can access the akin of cAMP, which could, therefore, be acclimated for the analysis of asthma and COPD. EC50 amount of Doxofylline is 15 times college than that of aminophylline in inhibiting the adenosine-induced alleviation of tracheal bland beef and 10 times college in abbreviation the abrogating inotropic aftereffect induced by adenosine on abandoned guinea-pig atria. Doxofylline could finer abatement the accessible anticipation of the calcium-activated potassium channels as a aftereffect of both the abridgement of accessible aeon and the assiduity of abutting time. Doxofylline has abundantly decreased affection appear adenosine A1 and A2 receptors if compared with theophylline, which may accord to the bigger assurance profile. Moreover, clashing theophylline, Doxofylline does not baffle with calcium arrival into beef nor antagonizes the activity of calcium-channel blockers.
Doxofylline has been apparent to accept bigger ability with beneath ancillary furnishings than theophylline. 30 mg/kg Doxofylline increases affection amount of anaesthetized cat by 13 beats/min. The able ameliorative dosage of Doxofylline has beneath cardio-stimulant furnishings than Theophylline, such that Doxofylline does not out decidedly access the cardiac abundance nor does it accept arrhythmogenic effects.