Dehydroepiandrosterone assembly is controlled by the academician in a abrogating acknowledgment loop. This agency that if dehydroepiandrosterone levels in the physique fall, the arrangement is ‘switched on’ and, as levels rise, it ‘switches off’ again.

The arrangement is ‘switched on’ by corticotrophin-releasing hormone getting produced by the hypothalamus. This campaign to the antecedent pituitary gland and causes it to absolution adrenocorticotropic hormone into the bloodstream. Both of these hormones could cause the adrenal glands to aftermath dehydroepiandrosterone. If dehydroepiandrosterone levels rise, the physique shuts off assembly by endlessly corticotrophin-releasing hormone and adrenocorticotropic hormone.