Reserpine has displayed a accommodation to arrest the carriage of biogenic amines into synaptic vesicles and adrenal chromaffin granules. The apparatus abaft this inhibition has been aflame as an irreversible bounden to the vesicular amine transporter. Furthermore, Reserpine has been appear to baffle with dopamine abettor action and potently arrest synaptosomal dopamine uptake. Reserpine is an inhibitor of VMAT 2.
Reserpine is an indole vinegaroid, aboriginal abandoned from the roots of Rauwolfia serpentina. Its use as a primary antihypertensive abettor to amusement mild-to-moderate hypertension and as an antipsychotic abettor has abundantly been discontinued. However, its use as a second-line accessory in aggregate with added antihypertensive drugs to administer the added astringent forms of hypertension and added antipsychotic drugs to administer analysis adverse psychosis is emerging. In veterinary medicine, reserpine is used as a long-acting ammunition and allaying for horses, cattle, dogs, and cats.