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Fidaxomicin is ailing absorbed; therefore, austere adverse furnishings are rare. There are no accepted drug-drug interactions or contraindications with use. Fidaxomicin should not be used for systemic infections, and should be used alone for infections accurate or acerb doubtable to be acquired by C. difficile. Fidaxomicin is a U.S. Food and Drug Administration abundance class B drug; it is not accepted whether it is excreted in animal milk.

Fidaxomicin has an adverse aftereffect contour commensurable to that of articulate vancomycin. In analytic trials of 564 patients, about 6 percent withdrew because of adverse effects. The a lot of accepted adverse furnishings (greater than 5 percent) were nausea, vomiting, and belly pain.

CAS: 132-20-7

Molecular Formula: C20H24N2O4

Molecular weight:356.42

Appearance:white powder

Pheniramine maleate is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.

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CAS No.: 119-64-2

Molecular Formula: C10H12

Tetralin (1,2,3,4-tetrahydronaphthalene) is a colorless, oily liquid with naphthalene odor. It is miscible with higher alcohols, diethyl ether and hydrocarbons; poorly soluble in metanol; practically insoluble in water and liquid ammonia. Tetralin contains in coal tar fractions and in some oils.

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CAS: 91-01-0

Molecular Formula: (C6H5)2CHOH

Molecular Weight: 184.23


Benzhydrol is broadly used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and added amoebic compounds. It is used as a fixative in the aroma industry. It is complex in polymerization acknowledgment as a absolute group. It is used as forerunner to adapt modafinil, benztropine and diphehydramine.

Irbesartan is a nonpeptide tetrazole acquired and an angiotensin II adversary that selectively blocks the bounden of angiotensin II to the AT1 receptor. In the renin-angiotensin system, angiotensin I is adapted by angiotensin-converting agitator (ACE) to anatomy angiotensin II. Angiotensin II stimulates the adrenal case to amalgamate and bury aldosterone, which decreases the elimination of sodium and increases the elimination of potassium. Angiotensin II aswell acts as a vasoconstrictor in vascular bland muscle.

Irbesartan, by blocking the bounden of angiotensin II to the AT1 receptor, promotes vasodilation and decreases the furnishings of aldosterone. The abrogating acknowledgment adjustment of angiotensin II on renin beard is aswell inhibited, but the consistent acceleration in claret renin concentrations and consistent acceleration in angiotensin II claret concentrations do not annul the claret pressure–lowering aftereffect that occurs. The activity of ARBs is altered from ACE inhibitors, which block the about-face of angiotensin I to angiotensin II, acceptation that the assembly of angiotensin II is not absolutely inhibited, as the hormone can be formed via added enzymes. Also, clashing ACE inhibitors, irbesartan and added ARBs do not baffle with acknowledgment to bradykinins and actuality P, which allows for the absence of adverse furnishings that are present in ACE inhibitors (eg. dry cough).

Lenalidomide, a thalidomide analogue, is an immunomodulatory abettor possessing immunomodulatory and antiangiogenic properties. Lenalidomide inhibits the beard of pro-inflammatory cytokines and increases the beard of anti-inflammatory cytokines from borderline claret mononuclear cells. Lenalidomide inhibits corpuscle admeasurement with capricious capability (IC50s) in some but not all corpuscle lines. Lenalidomide is able in inhibiting advance of Namalwa beef (a animal B corpuscle lymphoma corpuscle band with a abatement of one chromosome 5) but is abundant beneath able in inhibiting advance of KG-1 beef (human myeloblastic corpuscle line, aswell with a abatement of one chromosome 5) and added corpuscle curve after chromosome 5 deletions. Lenalidomide does not prolong the QTc interval.

The apparatus of activity of lenalidomide charcoal to be absolutely characterized, about it has been approved that lenalidomide inhibits the announcement of cyclooxygenase-2 (COX-2), but not COX-1, in vitro.

Nevirapine avalanche in the non-nucleoside about-face transcriptase inhibitor (NNRTI) chic of antiretrovirals.Both nucleoside and non-nucleoside RTIs arrest the aforementioned target, the about-face transcriptase enzyme, an capital viral agitator which transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the polymerase alive site, NNRTIs bind to a berserk abridged in the subdomain of p66 which is about 10 angstrom abroad from the alive website (known as the NNRTI pocket). Therefore, this NNRTI-binding abridged will arrest about-face archetype in a way that is audible to the NRTIs.

Nevirapine is not able adjoin HIV-2, as the abridged of the HIV-2 about-face transcriptase has a altered structure, which confers built-in attrition to the NNRTI class.

Resistance to nevirapine develops rapidly if viral archetype is not absolutely suppressed.The a lot of accepted mutations empiric afterwards nevirapine analysis are Y181C and K103N, which are aswell empiric with added NNRTIs.As all NNRTIs bind aural the aforementioned pocket, viral strains which are aggressive to nevirapine are usually aswell aggressive to the added NNRTIs, efavirenz and delavirdine. However, additional bearing NNRTIs like rilpivirine and etravirine are able in analysis for HIV strains aggressive to nevirapine and added aboriginal bearing drugs in that aforementioned class.