Lenalidomide, a thalidomide analogue, is an immunomodulatory abettor possessing immunomodulatory and antiangiogenic properties. Lenalidomide inhibits the beard of pro-inflammatory cytokines and increases the beard of anti-inflammatory cytokines from borderline claret mononuclear cells. Lenalidomide inhibits corpuscle admeasurement with capricious capability (IC50s) in some but not all corpuscle lines. Lenalidomide is able in inhibiting advance of Namalwa beef (a animal B corpuscle lymphoma corpuscle band with a abatement of one chromosome 5) but is abundant beneath able in inhibiting advance of KG-1 beef (human myeloblastic corpuscle line, aswell with a abatement of one chromosome 5) and added corpuscle curve after chromosome 5 deletions. Lenalidomide does not prolong the QTc interval.
The apparatus of activity of lenalidomide charcoal to be absolutely characterized, about it has been approved that lenalidomide inhibits the announcement of cyclooxygenase-2 (COX-2), but not COX-1, in vitro.